Eea1 Protein. Targeted protein degradation (TPD) is a promising new therapeutic modality and a tool for probing biological pathways as well as the cellular degradation machinery.
Morpho Functional Characterization Of The Endo Lysosomal System By High Throughput Correlative Light Electron Microscopy Biorxiv from biorxiv.org
The antibodies used for staining were antiEEA1 antiGM130 antigolgin97 antiVPS35 antiCIMPR anticlathrin heavy chain antiLAMP1 antiSNX1 antiSNX2 antiTGN46 (provided by D.
The lysosomal RagRagulator complex licenses RIPK1– and
During infection Yersinia inhibition of the protein kinase TAK1 triggers cleavage of the poreforming protein gasdermin D (GSDMD) (LAMP1 lysosomes KDEL endoplasmic reticulum MitoTracker mitochondria EEA1 early endosomes) and DAPI Scale bars 2 μm (C and D) Quantification of colocalization of cleaved caspase8 (C) and RIPK1 (D) with organelles in.
Morpho Functional Characterization Of The Endo Lysosomal System By High Throughput Correlative Light Electron Microscopy Biorxiv
LYTACs that engage the asialoglycoprotein receptor for
